Mavacamten

This page shows how to reproduce a dose-dependent response curve to a myotrope (Mavacamten).

Getting ready

• Open an Anaconda Prompt

• Activate the FiberSim Anaconda Environment by executing:

  conda activate fibersim
  

• Change directory to <FiberSim_dir>/code/FiberPy/FiberPy, where <FiberSim_dir> is the directory where you installed FiberSim.

Run the simulations

• Type:

  python FiberPy.py run_batch "../../../manuscripts/2021b/myotrope/batch_mava.json"
  

• You should see text appearing in the terminal window, showing that the simulations are running. When it finishes (this may take ~15 min), you should see something similar to the image below.

Viewing the results

The dose-dependent response is stored in <FiberSim_dir>/manuscripts/2021b/myotrope/sim_output

The underlying data are stored in <FiberSim_dir>/manuscripts/2021b/myotrope/sim_output/analysis.xlsx

The 10 subfolders from <FiberSim_dir>/manuscripts/2021b/myotrope/sim_output contain the simulations results and summary figures for each Mavacamten concentration.