Demo of simple twitch
This demo shows how to run a simulation of a single twitch
Instructions
- Launch MATLAB.
- Change directory to the
MATMyoSim\code\demos\getting_started\simple_twitch
folder in MATLAB. - Open
demo_simple_twitch_1.m
. - Press F5 to run the demo.
Code
function demo_twitch_1
% Function illustrates how to run a simulation of a single-half-sarcomere
% held isometric and activated by a transient pulse of Ca2+
% Variables
protocol_file_string = 'protocol.txt';
model_parameters_json_file_string = 'twitch_1_model.json';
options_file_string = 'twitch_1_options.json';
model_output_file_string = '..\..\temp\twitch_1_output.myo';
% Make sure the path allows us to find the right files
addpath(genpath('..\..\..\..\code'));
% Run a simulation
sim_output = simulation_driver( ...
'simulation_protocol_file_string', protocol_file_string, ...
'model_json_file_string', model_parameters_json_file_string, ...
'options_json_file_string', options_file_string, ...
'output_file_string', model_output_file_string);
% Load it back up and display to show how that can be done
sim = load(model_output_file_string,'-mat')
sim_output = sim.sim_output
figure(3);
clf;
subplot(2,1,1);
plot(sim_output.time_s,sim_output.muscle_force,'b-');
ylabel('Force (N m^{-2})');
subplot(2,1,2);
plot(sim_output.time_s,sim_output.hs_length,'b-');
ylabel('Half-sarcomere length (nm)');
Model
The model is defined in repo\code\demos\twitches\twitch_1\twitch_1.json
. See models for more details.
{
"MyoSim_model":
{
"code":
{
"version": "2.1.1"
},
"muscle_props":
{
"no_of_half_sarcomeres": 1,
"series_k_linear_per_hs": 0
},
"hs_props":
{
"kinetic_scheme": "3state_with_SRX",
"hs_length": 1300,
"myofilaments":
{
"bin_min": -10,
"bin_max": 10,
"bin_width": 0.5,
"thick_filament_length": 815,
"thin_filament_length": 1120,
"bare_zone_length": 80
},
"parameters":
{
"k_1": 1,
"k_force": 5e-4,
"k_2": 100,
"k_3": 100,
"k_4_0": 100,
"k_4_1": 0.1,
"k_cb": 0.001,
"x_ps": 5,
"k_on": 8e7,
"k_off": 200,
"k_coop": 1,
"int_passive_force_mode": "linear",
"int_passive_hsl_slack": 1265,
"int_passive_k_linear": 14,
"compliance_factor": 0.5,
"cb_number_density": 6.9e16,
"k_boltzmann": 1.38e-23,
"temperature": 288,
"max_rate": 5000
}
}
}
}
Output
Simulation output
Rates
Replotted from output file