Overview
MATMyoSim is software that simulates the mechanical properties of half-sarcomeres using cross-bridge distribution techniques. It is designed as a research tool that can be used to test hypotheses and to help produce new insights into experimental data.
Simulations
The calculations underlying the simulations are handled by the computer code. To run a simulation you only need to define:
- a model - how the cross-bridges cycle, the passive elastic component, and whether or not multiple half-sarcomeres are linked in series to form a myofibril
- a protocol - a sequence of instructions that define the experiment including: the activating Ca2+ concentration and any length changes or isotonic conditions that are imposed
- simulation options - which describe how to display the data and run the calculations and display data
Once you have your model, protocol, and simulation options, you can run a simulation by passing your model, protocol, and options text files to a single MATLAB function.
Other tools
Batch structures allow you to run several simulations in parallel. This is useful if you want to simulate a tension-pCa curve or investigate how a muscle responds to stretches of different speeds.
You can also fit models to experimental data using optimization structures. This process adjusts the parameter values in your model until the model predictions match the experimental data to some desired tolerance.
Next steps
To see examples, look at the demos
- Getting started is a good launching pad.